Sheng Mai San is an herbal blend of panax ginseng, ophiopogon tuber, and schizandra. All three herbs act together to tonify the qi, nourish the yin, and restrain leakage of fluids.

Related Studies
In heat stressed rats Sheng Mai San shown to mitigate the exhaustion of myocardial creatine phosphate and cAMP (Zhong et al. 1989). Renal protection against ischemia due to heat injury has been demonstrated by this formula's ability to reduce peroxynitrite formation and reduce plasma levels of creatinie and blood urea nitrogen (Lee et al. 2005). In yet another study, the formula was shown to reduce intracranial hypertension and ischemic brain damage as measured by free radical presence and lipid peroxidation (Wang e al., 2005). Stabilizing the energy store in the myocardium and preventing oxidative and ischemic brain and kidney stress will promote cardiac output and improved performance during intense physical exertion in the heat.

Citations:
Chang CK, Chang CP, Liu SY, Lin MT. Oxidative stress and ischemic injuries in heat stroke. Prog Brain Res. 2007;162:525-46. PMID: 17645935

Lee, I.Y., Lee, C.C., Chang C.K., Chien, C.H., Lin, M.T. 2005. Sheng mai San, a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke in the rat. Clin Exp Pharmacol Physiol. Sep; 32(9): 742-8. PMID: 16173931

Wang N, Minatoguchi S, Arai M, Uno Y, Nishida Y, Hashimoto K, Xue-Hai C, Fukuda K, Akao S, Takemura G, Fujiwara H. Sheng-Mai-San is protective against post-ischemic myocardial dysfunction in rats through its opening of the mitochondrial KATP channels. Circ J. 2002 Aug;66(8):763-8. PMID: 12197603

Wang, N.L., Chang, C.K., Liou, Y.L., Lin, C.L., Lin, M.T. 2005. Sheng Mai San, a Chinese herbal medicine, protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation. J Pharmacol Sci. May 98(1):1-7. PMID: 15879682

Wang, N.L., Liou, Y.L., Lin, C.L., Chang, C.K. 2005. Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J Pharmacol Sci. Feb;97(2): 253-65. PMID: 15699577

You JS, Huang HF, Chang YL, Lee YS. Sheng-mai-san reduces adriamycin-induced cardiomyopathy in rats. Am J Chin Med. 2006;34(2):295-305. PMID: 16552840

Zhang GQ, Wang H, Liu WT, Dong H, Fong WF, Tang LM, Xiong YH, Yu ZL, Ko KM. Long-term treatment with a Chinese herbal formula, Sheng-Mai-San, improves cardiac contractile function in aged rats: the role of Ca(2+) homeostasis. Rejuvenation Res. 2008 Dec;11(6):991-1000. PMID: 19072253